Milano Metropoli works closely with the public authorities operating in the metropolitan area of Milan and in partnership with local town councils, development agencies, universities and research centres, trade unions, the business community, banks, foundations and non-profit making organizations. 

The Agency also relies on a far-reaching network of national and international contacts and partnerships and takes an active part in numerous development agency networks:

• AIDA, the Italian association of local development and territorial marketing agencies (Milano Metropoli promoted its formation and has chaired it since 2003);
• EURADA, European Development Agency Association (the Agency has held the presidency since 2008);
• EBN, the European network of Business Innovation Centres
• LEED, Local Employment and Economic Development, in the OCED;
• RDA Net Ceda, East Europe
  
• Cabernet, the European Concerted Action on Brownfield and Economic Regeneration Network;
• Rete di Agenzie Centro Nord promoted by Formez
  
• Associazione Aree Urbane Dismesse (AUDIS)